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M9480087.TXT
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1994-08-09
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Document 0087
DOCN M9480087
TI Anti-HIV michellamines from Ancistrocladus korupensis.
DT 9410
AU Boyd MR; Hallock YF; Cardellina JH 2nd; Manfredi KP; Blunt JW; McMahon
JB; Buckheit RW Jr; Bringmann G; Schaffer M; Cragg GM; et al; Laboratory
of Drug Discovery Research & Development, National; Cancer
Institute-Frederick Cancer Research & Development Center,; Maryland
21702-1201.
SO J Med Chem. 1994 Jun 10;37(12):1740-5. Unique Identifier : AIDSLINE
MED/94293292
AB Here we report details of the isolation and determination of the
absolute configurations and comparative anti-HIV activities of novel,
atropisomeric naphthylisoquinoline alkaloid dimers, michellamines A, B,
and C, from a newly described species of Ancistrocladus from the Korup
rainforest of Cameroon. We further provide a more extensive analysis of
the range of anti-HIV activity of michellamine B, the most potent and
abundant member of the series. Michellamine B inhibited HIV-induced cell
killing and viral replication in a variety of human cell lines, as well
as in cultures of human peripheral blood leukocytes and monocytes.
Michellamine B was active against a panel of biologically diverse
laboratory and clinical strains of HIV-1, including the AZT-resistant
strain G910-6 and the pyridinone-resistant strain A17; the compound also
inhibited several strains of HIV-2.
DE Africa Antiviral Agents/CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY
Cells, Cultured Drug Interactions Human HIV/*DRUG EFFECTS/PHYSIOLOGY
HIV-1/DRUG EFFECTS HIV-2/DRUG EFFECTS
Isoquinolines/CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY Microbial
Sensitivity Tests Molecular Structure Naphthalenes/CHEMISTRY/ISOLATION
& PURIF/*PHARMACOLOGY Plants/*CHEMISTRY Support, Non-U.S. Gov't Virus
Replication/DRUG EFFECTS Zidovudine/PHARMACOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).